Treating Restless Legs Syndrome
Reviewed by our editorial team
Last updated: 2026-04-01

Treating Restless Legs Syndrome (RLS) is as much about managing the underlying cause as it is about relieving the symptoms. Because RLS is a neurological condition characterized by an irresistible urge to move the legs, treatment focuses on calming the nervous system and ensuring the brain has the nutrients it needs to function correctly.
For many, RLS symptoms are manageable with simple lifestyle adjustments. For others, particularly those whose sleep is severely disrupted, a combination of medical and behavioral interventions is necessary to achieve relief and restore quality of life.
Iron Deficiency and Supplementation
A common underlying factor in RLS is low iron levels in the brain, even if a standard blood test shows 'normal' iron levels. Doctors typically check a 'ferritin' level, which measures iron stores. If ferritin is below 75 ng/mL, iron supplementation is often the first and most effective treatment.
In some cases, oral iron is not well-absorbed or causes stomach upset. For these patients, an intravenous (IV) iron infusion can provide dramatic and long-lasting relief from RLS symptoms by bypassing the gut and directly increasing iron availability to the brain.
Lifestyle and Non-Drug Remedies
Simple daily changes can significantly reduce RLS severity. Avoiding triggers like caffeine, alcohol, and nicotine is essential. Regular moderate exercise is helpful, though very intense workouts late in the day can sometimes make symptoms worse.
During an RLS episode, many patients find relief through leg massages, hot or cold baths, or using a weighted blanket. Stretching routines, particularly those focused on the calves and hamstrings, can also help 'reset' the nervous system before bedtime.
Pharmacological Treatments
When lifestyle changes aren't enough, medications like gabapentin or pregabalin (alpha-2-delta ligands) are now the preferred first-line medical treatment. These medications help normalize the overactive signals in the nerves that cause the 'creepy-crawly' sensations.
Dopamine agonists were once the standard, but they are now used more cautiously. While they work quickly, long-term use can lead to 'augmentation,' where the symptoms begin earlier in the day and spread to the arms or other body parts. This requires a complex transition to a different medication class.
Reviewing Current Medications
An often overlooked part of RLS treatment is reviewing other medications the patient is taking. Many common drugs can worsen RLS, including sedating antihistamines (like Benadryl), many antidepressants, and certain anti-nausea medications.
If you have RLS, it is vital to discuss all your prescriptions with your doctor. Switching to a different type of antidepressant, for example, can sometimes eliminate RLS symptoms entirely without the need for additional 'sleep' medications.
Frequently Asked Questions
References
- [1]Restless Legs Syndrome Foundation. Treatment Options.
- [2]Mayo Clinic. Restless Legs Syndrome: Diagnosis & Treatment.
- [3]AASM. Management of Restless Legs Syndrome.
The information on this page is for educational purposes only and is not a substitute for professional medical advice. Always consult a qualified healthcare provider for diagnosis and treatment.